郝帅

1988.5

最高学历学位：博士研究生

职称：教授

导师类型：硕士，博士生导师

电子邮箱：haoshuai@btbu.edu.cn

个人简历

教育经历：

2010.09-2015.06，北京师范大学，细胞生物学，博士

2006.09-2010.07，北京理工大学，生物技术，学士

工作经历：

2025.01-至今， betway88官网手机版，betway88西汉姆网页，教授

2019.12-2024.12，betway88官网手机版，betway88西汉姆网页，副教授

2015.09-2019,11，betway88官网手机版，食品学院，讲师

主讲课程

本科生：《细胞生物学》，《食品生物技术概论（双语）》，《食品风险监测与评估》，《现代食品安全检测技术》，《食品加工过程质量控制》

主要研究领域

食源性功能因子在肿瘤及营养代谢疾病中的递送，干预及分子机制研究，功能性食品评价与开发，细胞与营养代谢

主要学术成果（课题、论文、专利、获奖等）

承担的主要科研项目（限5项）：

1、主持国家自然科学基金青年科学基金项目，基于动态蛋白质组技术对藻蓝色素蛋白生物合成及组装机制的研究，2018.01 - 2020.12

2、主持国家自然科学基金面上项目，“肠道菌群-microRNA轴”介导藻蓝色素干预糖代谢的分子机制研究，2021.01 - 2024.12

3、主持国家自然科学基金面上项目，基于肠道“3D”类器官模型解析细胞自噬参与藻蓝色素改善肠屏障的分子机制研究，2023.01 - 2026.12

4、主持北京市属高校教师队伍建设支持计划优秀青年人才项目，miR-122-5p参与藻蓝色素改善糖代谢的功能和机制研究，2023.01-2025.12

5、主持北京市教育委员会科研计划一般项目，藻蓝色素介导炎性抑制反应的功能及其动态调控机制研究，2021.01-2023.12

发表的代表性论文（限10篇）：

1. Boxiong Wu, Haozhe Cheng, Xinran Li, Qi Yang, Wenjing Zhang, Shuai Hao*, Chengtao Wang. Phycocyanin-derived bioactive peptide PCP3 ameliorates lipopolysaccharide-induced small intestinal inflammation in murine intestinal organoids and mice through regulating Akt and AMPK/autophagy signaling, Food Bioscience, 2024, 60: 104419.

2. Boxiong Wu, Haozhe Cheng, Xinran Li, Qi Yang, Shuai Hao*, Chengtao Wang, Baoguo Sun. Identification and functional analysis of phycocyanin-derived bioactive peptides with non-small cell lung cancer cell inhibition, Algal Research-Biomass biofuels and Bioproducts, 2024, 79: 103467.

3. Wenjing Zhang, Boxiong Wu, Haozhe Cheng, Fannian Li, Qiancheng Li, Shuai Hao*. miR-338-3p and miR-34a-5p act as antagonists in phycocyanin-mediated process of ameliorating glycometabolism in T2DM HepG2 cells, Journal of Functional Foods, 2024, 112: 105959.

4. Shuai Hao*, Qi Yang, Wenjing Zhang, Qiancheng Li, Fannian Li, Haozhe Cheng, Boxiong Wu. LINC00852 participates in the phycocyanin-mediated restrained vitality of non-small cell lung cancer cells via miR-29a-3p/LAMTOR1 axis, Journal of Functional Foods, 2023, 106: 105588.

5. Shuai Hao*, Fannian Li, Qiancheng Li, Qi Yang, Wenjing Zhang. Phycocyanin protects against high glucose high fat diet induced diabetes in mice and participates in AKT and AMPK signaling, Foods, 2022, 11, 3183.

6. Shuai Hao, Fannian Li, Yuanpu Liu, Qi Yang, Qiancheng Li, Wenjing Zhang, Chengtao Wang*. Phycocyanin diminishes the viability of non-small cell lung cancer cells via induction of autophagy, Journal of Functional Foods, 2022, 94: 105145.

7. Shuai Hao, Qiancheng Li, Yuanpu Liu, Fannian Li, Qi Yang, Jing Wang and Chengtao Wang*. Insulin receptor substrate 1 is involved in the phycocyanin-mediated antineoplastic function of non-small cell lung cancer cells, Molecules, 2021, 26, 4711.

8. Shuai Hao, Jing Wang, Shuang Li, Feng Shang, Yu Qin, Tingting Wu, Xi Bao, Qi Cao, Chengtao Wang*, Baoguo Sun. Preparation of gardenia red pigment and its antineoplastic activity in multiple tumor cells, Food Bioscience, 2020, 35: 100582.

9. Shuai Hao*, Shuang Li, Jing Wang, Lei Zhao, Chan Zhang, Weiwei Huang, Chengtao Wang*. Phycocyanin reduces proliferation of melanoma cells through downregulating GRB2/ERK signaling, Journal of Agricultural and Food Chemistry, 2018, 66: 10921-10929.

10. Shuai Hao*, Shuang Li, Jing Wang, Lei Zhao, Yan Yan, Tingting Wu, Jiawen Zhang, Chengtao Wang*. C-Phycocyanin suppresses the in vitro proliferation and migration of non-small-cell lung cancer cells through reduction of RIPK1/NF-κB activity, Marine Drugs, 2019, 17, 362.

授权的国家发明专利（限10项）

1、一种藻蓝蛋白肽及其在改善肠道炎症中的应用，ZL 2024 1 0078959.0

2、一种藻蓝蛋白抗肿瘤肽及其制备方法和应用，ZL2022114542486

3、一种花香低盐腐乳膏发酵生产方法，ZL 2020 1 0708900.7

4、一种基于碳酸钙的食用色淀的制备方法，ZL201910512968 .5